Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution

The use of high-throughput sequencing techniques revealed the dynamic plasticity of the transcriptional landscape as a function of environmental, developmental and genetic factors of transcriptomes under multiple conditions: rapid proliferation, meiotic differentiation, environmental stress, and in RNA processing mutants.

http://www.nature.com/nature/journal/v453/n7199/full/nature07002.html

Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.

Strong data suggesting extensive connections between the RBP and miRNA post-transcriptional regulatory systems thereby providing perhaps a framework for deciphering the molecular mechanism by which PUF proteins regulate their target mRNAs.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18776931